I work on conceptual questions in the philosophy of biology, psychology and medicine, and their ramifications in philosophy of mind, metaphysics and epistemology. These include the nature of pain, biopsychosocial approaches in medicine and biomedical research, epistemology and metaphysics of causal and mechanistic explanations, the explanatory role of mathematical models and computer simulations, the philosophy of experimental research, l extrapolation and generalization in life sciences, gene concepts and species concepts.